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IMMUNE CHECKPOINT ASSAYS
CTLA-4 (CD152), PD-1 (CD279), PD-L1 (CD274), OX40 (CD134), 4-1bb (CD137), ICOS (CD278), TIM-3, LAG-3, TIGIT, TGIT ligand (CD155), CD96, CD226, GITR, BTLA etc.
Assays to evaluate functional impact of biologics or small molecules can be performed with appropriate cell lines relevant to immune checkpoints.
Assays to assess activated markers (co-stimulatory or co-inhibitory) and cytokine expression can be performed with primary cells in the presence of biologics or small molecules.
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